Two common polymorphisms in the 3′ untranslated regions of adenosine triphosphate-binding cassette B1 and C1 (ABCB1 and ABCC1) are linked to a greater risk of developing lung cancer, according to research published online Dec. 23 in Cancer.Haijian Wang, Ph.D., of Fudan University in Shanghai, China, and colleagues genotyped six common regulatory single-nucleotide polymorphisms of ABCB1 and ABCC1, using blood samples from 500 patients with lung cancer and 517 controls without lung cancer. ABCC1 has been shown to be involved in the elimination of metabolites of the tobacco carcinogen NNK, and ABCB1 removes harmful agents in the lungs.