Markers of gene activation predicts lung cancer recurrence
March 27th, 2008
The switching on and off of a specific set of genes, or methylation, in patients with stage I non-small-cell lung cancer (NSCLC) appears to increase the risk of recurrence following surgery, researchers are reporting. In fact, when two of these genes were methylated (or switched off) in tissue samples from the tumor and mediastinal lymph nodes, the recurrence risk increased as much as 25-fold.