An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth
A rationally designed small molecule inhibitor can specifically
bind with Dishevelled protein, a key modulator in the Wnt signaling pathway that is overexpressed in the majority of lung cancer. This binding blocks the protein-protein interaction between Dishevelled and the Wnt receptor Frizzled protein suppresses the Wnt signaling pathway
in lung cancer, decreasing proliferation and inducing apoptosis. This is the first evidence that a non-peptide small molecule can specifically inhibit Wnt signaling.
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